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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)

Pivoting back to the obesity space, a year-long Phase 2 study comparing semaglutide daily to 0.6 mg of liraglutide daily and placebo demonstrated the superiority of semaglutide over liraglutide in all doses above 0.2 mg (NCT02453711)

injections of 50 nmol kg 1 GLP-1MK-801 ( n = 6 mice and n = 3 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) for 6 days